lysine methyltransferase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1841	UNC0379		Histone Methyltransferase
	UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.		Histone Methyltransferase
T17203	UNC0224		Histone Methyltransferase
	UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.		Histone Methyltransferase
T4583	PFI-2 hydrochloride	(R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.		Histone Methyltransferase
T1987	PFI-2	PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase
	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.		Histone Methyltransferase
T7305	JQEZ5		Histone Methyltransferase
	JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).		Histone Methyltransferase
T14841	BVT948		Phosphatase , P450 , Histone Methyltransferase
	BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).		Phosphatase , P450 , Histone Methyltransferase
T6879	LLY-507	LLY507,LLY 507	Histone Methyltransferase
	LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.		Histone Methyltransferase
TQ0232	UNC0646	UNC 0646	Histone Methyltransferase
	UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) potently blocks G9a/GLP methyltransferase activity in cells ...		Histone Methyltransferase
T25471	GSK-A	GSK A
	GSK-A is a Histone Lysine Methyltransferase EZH2 inhibitor.
T10553	BIX-01338 hydrate		Others
	BIX-01338 hydrate is an inhibitor of histone lysine methyltransferase.		Others
T28111	MS012	MS-012,MS 012
	MS012 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase (Kd = 46 ± 15 nM).
T36799	UNC 2399
	Biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells. Negative control also avilable. 0
T40993	Histone H3 (1-21)	Histone H3 (1-21)
	Histone H3 (1-21) is a truncated form of the Histone H3 protein consisting of amino acids 1 to 21. It serves as a common substrate for methyltransferase assays targeting Histone 3 at lysine 4 and lysine 9, as well as for...
T69624	TC-5115
	TC-5115 is a potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. TC-5115 may lead to the development of a new therapy for the treatment of human MLL leukemia. The mixed-lineage leukemia (MLL) protein, al...
T11185	EML741		Histone Methyltransferase
	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase...		Histone Methyltransferase
T26744	BAY-598 R-isomer	BAY598 R-isomer,BAY 598 R-isomer
	BAY-598 R-isomer is the R-isomer of BAY589, which is used as a reference compound. It is is an inhibitor of lysine N-methyltransferase (SMYD2) and is selective for SMYD2 over protease-activated receptor 1 (PAR1).
T63705	UNC0379 TFA
	UNC0379 TFA is a selective, substrate competitive inhibitor of lysine methyltransferase SETD8 (KMT5A) (IC50: 7.3 μM) and exhibits good selectivity for 15 other methyltransferases.
T28114	MS2177	MS 2177,MS-2177
	MS2177 is a potent and selective inhibitor of SETD8, the only methyltransferase known to catalyze monomethylation of histone H4 lysine 20 (H4K20). MS2177 has an in vitro IC50 of 1.9 μM (σ = 1.05 μM, n = 4) in ascintillat...
T36802	Bisubstrate Inhibitor 78
	Bisubstrate inhibitor 78 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50= 1.41 μM).1It binds the NNMT active site in the binding pockets for the NNMT substrates S-adenosyl-L-methionine (SAM) and nicotinam...
T81175	SETD7-IN-1		Histone Methyltransferase
	SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory concentration (IC50) of 0.96 ± 0.10 µM [1].		Histone Methyltransferase